Analysis of the algorithm: From rankings to backup genes.

Ranking section

For each of the affected genes present in the list, a ranking with the score and percentile of every possible gene was obtained. Once this was done, the position for every known backup gene was obtained and the statistical descriptor of all the values calculated.

Table 1. Backup position values for every kernel and net before integration.

Net Kernel Elements Min Max Average Standard_Deviation
biological_process ct 68 0.0 0.718 0.082 0.168
biological_process el 68 0.059 0.965 0.61 0.247
biological_process ka 68 0.0 0.679 0.08 0.168
biological_process rf 68 0.0 0.718 0.082 0.168
cellular_component ct 67 0.0 0.879 0.124 0.197
cellular_component el 69 0.009 0.997 0.458 0.273
cellular_component ka 69 0.0 0.886 0.126 0.198
cellular_component rf 69 0.0 0.868 0.123 0.194
disease ct 22 0.001 0.841 0.135 0.242
disease el 22 0.005 0.695 0.18 0.221
disease ka 22 0.0 0.851 0.136 0.249
disease rf 22 0.001 0.841 0.134 0.242
genetic_interaction el 62 0.049 0.996 0.521 0.279
genetic_interaction ka 62 0.0 0.996 0.387 0.321
genetic_interaction rf 62 0.0 0.996 0.386 0.321
interaction ct 69 0.0 0.741 0.035 0.123
interaction el 69 0.0 0.779 0.039 0.135
interaction ka 69 0.0 0.969 0.183 0.291
interaction rf 69 0.0 0.74 0.035 0.122
molecular_function ct 69 0.0 0.994 0.148 0.282
molecular_function el 69 0.048 0.993 0.472 0.298
molecular_function ka 69 0.0 0.97 0.147 0.28
molecular_function rf 69 0.0 0.994 0.147 0.282
pathway ct 30 0.001 0.996 0.069 0.18
pathway el 30 0.001 0.185 0.027 0.047
pathway ka 30 0.001 0.865 0.173 0.272
pathway rf 30 0.001 0.157 0.03 0.044
phenotype ct 24 0.0 0.868 0.211 0.28
phenotype el 24 0.03 0.847 0.488 0.2
phenotype ka 24 0.0 0.967 0.225 0.311
phenotype rf 24 0.0 0.861 0.21 0.279
protein_interaction ct 71 0.0 0.741 0.034 0.121
protein_interaction el 71 0.0 0.779 0.038 0.133
protein_interaction ka 71 0.0 0.969 0.178 0.289
protein_interaction rf 71 0.0 0.74 0.034 0.121

Table 2. Backup position values for every kernel after integration

Integration Kernel Elements Min Max Average Standard_Deviation
integration_mean_by_presence ct 69 0.0 0.876 0.122 0.248
integration_mean_by_presence el 69 0.0 0.862 0.197 0.232
integration_mean_by_presence ka 69 0.0 0.814 0.062 0.167
integration_mean_by_presence rf 69 0.0 0.321 0.025 0.063
mean ct 69 0.0 0.867 0.099 0.231
mean el 69 0.0 0.805 0.111 0.181
mean ka 69 0.0 0.575 0.037 0.102
mean rf 69 0.0 0.327 0.033 0.078

CDF plots of non integrated kernels

CDF plots of integrated kernels